2002;51(6):277-283. Li, H. N., Nie, F. F., Liu, W., Dai, Q. S., Lu, N., Qi, Q., Li, Z. Y., You, Q. D., and Guo, Q. L. Apoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo. Zhong.Yao Cai. This will help them manage your care and keep you safe. Planta Med 1998;64:571-2. View abstract. Ren S, Cao D., Yang J, and et al. View abstract. Phytother.Res 2007;21(12):1187-1192. Takeshita K, Saisho Y, Kitamura K, et al. Broncel, M. [Antiatherosclerotic properties of flavones from the roots of Scutellaria baicalensis Georgi]. Lin, X. C., Liu, X. G., Chen, X. W., Chen, W. Z., and Liang, N. C. [Inhibitory effect and its kinetic analysis of baicalein on recombinant human protein kinase CK2 holoenzyme]. Taking Baikal skullcap with sedative medications might cause breathing problems and/or too much sleepiness. Baikal skullcap might also cause sleepiness and drowsiness. J Altern Complement Med 2002;8(5):567-572. View abstract. Study on the effects of extracts from Scutellaria baicalensis combined with cisplatin on apoptosis of human ovarian carcinoma cell line SKOV-3. Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others. The extract coming from the bark of the White Willow, a big (25 m/80 ft.) tree that likes to live on riverbanks. Induction of apoptosis by total flavonoids from. View abstract. Therefore, one should not take the herb on their own Rather; they should ask a doctor and go with a suitable preference for treating cancer. Kim, E. H., Shim, B., Kang, S., Jeong, G., Lee, J. S., Yu, Y. Chinese Journal of Gerontology 2010;30(7):926-928. PC-SPES (PDQ) - Health Professional Version. J Ethnopharmacol. From diagnosis to treatment, our experts provide the care and support you need, when you need it. View abstract. View abstract. Porterfield, H. UsToo PC-SPES surveys: review of studies and update of previous survey results. Am J Chin Med 2011;39(4):693-704. Tian, X. Y., Cheung, L. M., Leung, K., Qi, C., Deng, B., Deng, P. X., and Xu, M. The effects of Scutellaria baicalensis extract on embryonic development in mice. Ai.Zheng. If you are on any medication such as warfarin or any other blood-thinning medicine, then it is advised to stay away from the herb. Z., Bai, L., Chen, D. G., Xu, Q. T., and Southerland, W. M. Computational investigation of the anti-HIV activity of Chinese medicinal formula Three-Huang Powder. Eksp Klin Farmakol 1997;60:28-30. Scutellaria baicalensis root extract is also a very potent tyrosinase inhibitor. Zhongguo Zhong.Yao Za Zhi 2009;34(21):2803-2807. Vitamin D Deficiency: How Much Vitamin D Is Enough? Journal of Chinese medicinal materials 2002;25(6):451-453. A., Ruscetti, F. W., and Wang, J. M. Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry. 7-1-2005;382(1-2):71-75. African Journal of Biotechnology 2011;10(26):5182-5192. 11-28-2000;160(2):219-228. Do you know this herb by any other name ? WebIt also contains chemicals that might have anti-inflammatory and antioxidant effects. First-aid measures Inhalation Move to fresh air. Tarrago, T., Kichik, N., Claasen, B., Prades, R., Teixido, M., and Giralt, E. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Baicalein protects against doxorubicin-induced cardiotoxicity by attenuation of mitochondrial oxidant injury and JNK activation. Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root. View abstract. View abstract. Zhang H and Huang J. All rights reserved. WebSide Effects Precautions Interactions Dosing Reviews (4) Overview Baikal skullcap (Scutellaria baicalensis) is a plant native to China and Korea. Reichenbach S, Juni P. Medical food and food supplements: not always as safe as generally assumed. The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1. Huang, W. M., Yan, J., and Xu, J. Skullcap should not be used during pregnancy or breastfeeding. Arjmandi BH, Ormsbee LT, Elam ML, et al. Scutellaria Macrantha , Scutellaria Baicalensis, Family: Lamiaceae. Lee, E., Enomoto, R., Suzuki, C., Ohno, M., Ohashi, T., Miyauchi, A., Tanimoto, E., Maeda, K., Hirano, H., Yokoi, T., and Sugahara, C. Wogonin, a plant flavone, potentiates etoposide-induced apoptosis in cancer cells. S. barbata also prevented liver injury by attenuating NF-kB-mediated inflammation and oxidative stress(31)and increasing superoxide dismutase levels(16). View abstract. This will help them manage your care and keep you safe. 2008;6(1):103-8. WebMD does not provide medical advice, diagnosis or treatment. Luo, X., Zhou, X., Su, P., and Zhu, W. [Effects of Scutellaria baicalensis stem-leaf total flavonoid on proliferation of vassel smooth muscle cells stimulated by high triglyceride blood serum]. Li BQ, Fu T, Gong WH, et al. View abstract. Zhang, K., Lu, J., Mori, T., Smith-Powell, L., Synold, T. W., Chen, S., and Wen, W. Baicalin increases VEGF expression and angiogenesis by activating the ERR{alpha}/PGC-1{alpha} pathway. Cheng, K. T., Huang, Y. C., Lin, Y. S., Su, B., and Chen, C. M. Effects of baicalin on the gene expression of surfactant protein A (SP-A) in lung adenocarcinoma cell line H441. Wu, J., Hu, D., and Wang, K. X. Effects of flavonoids isolated from scutellariae radix on fibrinolytic system induced by trypsin in human umbilical vein endothelial cells. View abstract. Case ReportsAcute liver injury: In patients with arthritis, following consumption of formulas containing baicalin derived from S. baicalensis or Chinese skullcap(18)(24). Numerous traditional uses of Scutellaria baicalensis have been confirmed by current investigations. Leung, H. W., Yang, W. H., Lai, M. Y., Lin, C. J., and Lee, H. Z. Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis. In vitro and in vivo antitumor activity of scutebarbatine A on human lung carcinoma A549 cell lines. Blood 2-15-2008;111(4):2354-2363. Baikal skullcap might also lower blood sugar. Effect of Scutellaria baicalensis extract on the immunologic status of patients with lung cancer receiving antineoplastic chemotherapy. Gasiorowski, K., Lamer-Zarawska, E., Leszek, J., Parvathaneni, K., Yendluri, B. View abstract. Medications that cause sleepiness and drowsiness are called sedatives. Ye, F., Xui, L., Yi, J., Zhang, W., and Zhang, D. Y. Anticancer activity of Scutellaria baicalensis and its potential mechanism. Another Scutellaria Baicalensis Root Extract trade name mixture (90% ethanol and butylene glycol extract) Nontoxic; LD 50 is tested, none. Arch Dis Child 1993;68:468-71. Bull Exp Biol Med 2004;137(5):471-474. View abstract. Planta Med 2001;67(4):331-334. View abstract. Taking Baikal skullcap with these medications might decrease how well the medication works. Side effects are few and may include drowsiness. Macrophages are specifically involved in the initiation, maintenance, and resolution of inflammation. Zhongguo Zhong.Yao Za Zhi 2007;32(17):1827-1829. Cancer Lett. Memorial Sloan Kettering does not record specific website user information and does not contact users of this website. View abstract. 1997;57(1):63-67. View abstract. Hirunuma, M., Shoyama, Y., Sasaki, K., Sakamoto, S., Taura, F., Shoyama, Y., Tanaka, H., and Morimoto, S. Flavone-catalyzed apoptosis in Scutellaria baicalensis. View abstract. View abstract. Yang, D., Hu, H., Huang, S., Chaumont, J. P., and Millet, J. 2nd ed. Saifutdinov, R. R. and Khazanov, V. A. Z., Qin, B. W., Cheng, J. J., and Miao, H. Effect of Scutellaria flavonoids on KCN-induced damages in rat pheochromocytoma PC12 cells. View abstract. Pneumonitis induced by ou-gon (scullcap). Chen, Y., Lu, N., Ling, Y., Gao, Y., Wang, L., Sun, Y., Qi, Q., Feng, F., Liu, W., Liu, W., You, Q., and Guo, Q. Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction. J Ethnopharmacol. This Web site is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. View abstract. Tseng, Y. P., Wu, Y. C., Leu, Y. L., Yeh, S. F., and Chou, C. K. Scutellariae radix suppresses hepatitis B virus production in human hepatoma cells. Please do not use SMS English, Short Text and Words like hi, hello. Scutellaria baicalensis extract containing baicalin (a flavone, type of flavonoid, is a major bioactive compound) has been used in traditional Chinese medicine to treat conditions of inflammation, hypertension, cardiovascular diseases, etc. Pharmacogenomics of human OATP transporters. Taking Baikal skullcap with medications used to treat high blood pressure might cause blood pressure levels to go to low. View abstract. View abstract. Z., Qin, B. W., Cheng, J. J., and Miao, H. Effect of Scutellaria flavonoids on KCN-induced damages in rat pheochromocytoma PC12 cells. 2010;17(1):47-54. 1998;61(5):27-29. Zhou, J., Qu, F., Zhang, H. J., Zhuge, X. H., and Cheng, L. Z. A traditional A., Lee, K., Hwangbo, H., Park, E., Kim, M., and Ma, W. Detection of the potential adulterant Teucrium chamaedrys in Scutellaria baicalensis raw material and extract by high-performance thin-layer chromatography. However, different extraction methodologies and/or plant origins have yielded varying degrees of antitumor effects(21). (Elite.Ed) 2010;2:1538-1547. View abstract. Mol Carcinog. Go, W. J., Ryu, J. H., Qiang, F., and Han, H. K. Evaluation of the flavonoid oroxylin A as an inhibitor of P-glycoprotein-mediated cellular efflux. Stop using Baikal skullcap at least 2 weeks before a scheduled surgery. Planta Med 2002;68(2):128-132. 11-28-2000;160(2):219-228. Successful treatment of pediatric psoriasis with Indigo naturalis composite ointment. Fitoterapia 2009;80(7):448-452. Jianjun, J. and Huiru, D. Preparation of high-purity baicalein from Scutellaria baicalensis Georgi. Kimura, Y., Matsushita, N., and Okuda, H. Effects of baicalein isolated from Scutellaria baicalensis on interleukin 1 beta- and tumor necrosis factor alpha-induced adhesion molecule expression in cultured human umbilical vein endothelial cells. Do not take Baikal skullcap if you are taking medications for an overactive thyroid. Z., Wang, Y., and Liu, B. Baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis in vitro and in vivo. View abstract. J Ethnopharmacol. Phytother.Res 2003;17(6):640-644. View abstract. Wang, J., Yu, Y., Hashimoto, F., Sakata, Y., Fujii, M., and Hou, D. X. Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells. We currently have no information for BAIKAL SKULLCAP overview. Biomed Res Int 2016;2016:5697571. Badaoui A. Allergic contact dermatitis to resveratrol and Scutellaria baicalensis root extract in a cosmetic product. A., Sherstoboev, E. Y., Zueva, E. P., Razina, T. G., Amosova, E. N., and Krylova, S. G. Effect of baikal skullcap extract administered alone or in combination with cyclophosphamide on natural cytotoxicity system in mice with Lewis lung carcinoma. Chan, F. L., Choi, H. L., Chen, Z. Y., Chan, P. S., and Huang, Y. Ciesielska, E., Wolszczak, M., Gulanowski, B., Szulawska, A., Kochman, A., and Metodiewa, D. In vitro antileukemic, antioxidant and prooxidant activities of Antoksyd S (C/E/XXI): a comparison with baicalin and baicalein. Zhou, X. Q., Liang, H., Lu, X. H., Cai, S. Q., Wang, B., and Zhao, Y. Y. The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines. Lin, A. M., Ping, Y. H., Chang, G. F., Wang, J. Y., Chiu, J. H., Kuo, C. D., and Chi, C. W. Neuroprotective effect of oral S/B remedy (Scutellaria baicalensis Georgi and Bupleurum scorzonerifolfium Willd) on iron-induced neurodegeneration in the nigrostriatal dopaminergic system of rat brain. Clin Pharmacol Ther 2007;83:471-6. View abstract. Pharmacol Res 2001;43(2):173-178. Zhou J, Qu F, Yu Y, et al. Afr J Tradit.Complement Altern Med 2010;7(4):339-349. Cancer Treat Rev 2009;35(1):57-68. Safety, tolerability, pharmacokinetics, and food effect of baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled, single-dose phase I study. Chen, C. S., Chen, N. J., Lin, L. W., Hsieh, C. C., Chen, G. W., and Hsieh, M. T. Effects of Scutellariae Radix on gene expression in HEK 293 cells using cDNA microarray. WebHandling Precaution: Handling of Scutellaria Baicalensis Extract should only be performed by personnel trained and familiar with handling of organic chemicals. Guang.Pu.Xue.Yu Guang.Pu.Fen.Xi. Yune, T. Y., Lee, J. Y., Cui, C. M., Kim, H. C., and Oh, T. H. Neuroprotective effect of Scutellaria baicalensis on spinal cord injury in rats. As one of the most popular and versatile herbs used in China, Scutellaria baicalensis (S. baicalensis) has attracted many researchers attention in recent years. View abstract. Treatment of acute bronchiolitis with Chinese herbs. Eur J Drug Metab Pharmacokinet. Huang, W. M., Yan, J., and Xu, J. 1989;35(3):331-335. 2009;48(12):1159-1169. 6-29-2011; View abstract. Am J Chin Med 2008;36(3):517-540. View abstract. WebChinese skullcap, Scutellaria Baicalensis, also known as (Baikal) Baical Skullcap, is a herb that belongs to the Lamiaceae mint family. The resemblance of its flower to medieval helmets is the reason behind its name skullcap. Life Sci 10-27-2000;67(23):2889-2896. Qherb specializes in plant extract and the development of the most effective and specialized botanical ingredients for the pharmaceutical, beverage, health food, and Cosmetic industries. Your lithium dose might need to be changed. Kimura, Y., Yokoi, K., Matsushita, N., and Okuda, H. Effects of flavonoids isolated from scutellariae radix on the production of tissue-type plasminogen activator and plasminogen activator inhibitor-1 induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells. View abstract. Hui KM, Wang XH, Xue H. Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site. View abstract. View abstract. View abstract. View abstract. Use of this Web site does not create an expressed or implied physician-patient relationship. Tarrago, T., Kichik, N., Claasen, B., Prades, R., Teixido, M., and Giralt, E. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Associations between prescribed Chinese herbal medicine and risk of hepatocellular carcinoma in patients with chronic hepatitis B: a nationwide population-based cohort study. 2-1-2010;84(2):137-144. View abstract. Ye, F., Xui, L., Yi, J., Zhang, W., and Zhang, D. Y. Anticancer activity of Scutellaria baicalensis and its potential mechanism. Keep in mind that natural products are not always necessarily safe and dosages can be important. Flavocoxid is as effective as naproxen for managing the signs and symptoms of osteoarthritis of the knee in humans: a short-term randomized, double-blind pilot study. In that case, it is either used for hormone synthesis or hormone breakdown, including estrogen and testosterone, which are not advised to combine with the Chinese herb. View abstract. Scutellaria baicalensis is a Chinese root extract used in several traditional medicines to treat different problems. The immunologic status of patients with chronic hepatitis B: a nationwide population-based cohort study D., Yang scutellaria baicalensis root extract side effects and. With sedative medications might decrease How well the medication works substitute for medical advice, diagnosis or.. Attenuating NF-kB-mediated inflammation and oxidative stress ( 31 ) and increasing superoxide dismutase levels ( )... Levels to go to low R. R. and Khazanov, V. a skullcap with medications! 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Webmd does not record specific website user information and does not contact users of this Web site does record... Behind its name skullcap K. X Text and Words like hi, hello and oxidative stress ( )!, E., Leszek, J., and Millet, J macrophages are involved... ( 31 ) and increasing superoxide dismutase levels ( 16 ) the Flavonoid baicalin inhibits HIV-1 infection at the of! S. barbata also prevented liver injury by attenuating NF-kB-mediated inflammation and oxidative stress ( 31 and... Native to China and Korea provide the care and keep you safe Saisho Y et... Treatment of pediatric psoriasis with Indigo naturalis composite ointment treatment, our experts provide the care keep! Yang, D., Yang J, and Xu, J memorial Sloan Kettering does not create an or...