They may give you painkillers to help. I also have been left with painful feet which I did mention but not until after all my chemo had finished! Capecitabine is FDA-approved as first-line treatment of patients with metastatic colorectal carcinoma when treatment with 5-FU therapy alone is preferred. If you have a stoma, it will be more active than usual. Help to Overcome Problems Effectively. You may get sore and red palms of hands and soles of feet. Many facilities will have programs with finanical assistance, like MSK can set up payment plans and the rest to make it easier. I will start adjuvant (mop-up) chemotherapy on April 24, with oral Capecitabine (Xeloda) and IV oxilaplatin. Depending on your needs, you may have between 4 and 8 cycles. Cancer and some cancer treatments can increase the risk of a blood clot. The difference in my mum was amazing and just gave her some quality of life again . Isle of Man company number 4694F. If you have an intolerance to lactose, contact your doctor before taking this medicine. Hi: I found out I had a tumor in my upper colon on February 7, 2017. Let your healthcare team know straight away if you have any bleeding. This is because they can make you unwell. I had it surgically removed on March 22. You'llneed to have some warm or hot drinks handy if you get the throat reaction. Introduction & Objective: The combination of oxaliplatin and capecitabine has demonstrated its effect against various gastrointestinal cancers. So I had ginger snaps guilt free. I used to leave feeling woozy, and now I feel alright. And women might be able to store eggs or ovarian tissue. If you are worried about this, it is important to talk with your doctor before you start treatment. What's going on near you? Contact your advice line, doctor or nurse immediately if you have signs of infection, such as a temperature above 37.5C or below 36C, or if you develop a severe skin reaction. Oxaliplatin is a third-generation platinum compound in which the platinum atom is complexed with a 1.2 diamino-cyclohexane and with an oxalate ligand as a leaving group. Dont breastfeed during this treatment and for 2 weeks after your final treatment. Welcome. If you develop any signs or feel unwell after you get home, contact the hospital straight away. The capecitabine and oxaliplatin with RT group received identical postoperative RT to that in the capecitabine with RT group combined with capecitabine (1300 mg/m 2) on days 1 to 14 and 22 to 35 and a 2-hour infusion of oxaliplatin (60 mg/m 2) on weeks 1, 2, 4, and 5. I was good for over a year and now I have two mets in one lung so I'm on Xeloda for that. A low white blood cell count is sometimes called neutropenia. You must take tablets according to the instructions your doctor or pharmacist gives you. Depending on your needs, you may have between 4 and 8 cycles. If your immune system is weak, you need to avoid live vaccinations. If you cannot get through, call the NHS urgent advice number which is 111. It is important to keep hands and feet well moisturised. Try to drink at least 2 litres (3 pints)of fluids each day. I actually responded well to avastin. I had my port-a-cath implanted a day before my first infusion. Most people get it along with Xeloda. Encorafenib and Cetuximab Metastatic Colorectal Cancer Protocol V1.1. There, that sounded less commanding. Capecitabine, Fluorouracil, and Oxaliplatin. tell your nurse or doctor they can give you a mouthwash or medicines to help. But it has subsided. Save these numbers in your phone or keep them somewhere safe. Just started FOLFOX on April 14/17. Your nurse will give you telephone numbers for the hospital. Progression-free survival and response rates did not differ significantly among the regimens. You can visit the electronic Medicines Compendium (eMC) for more detailed information about your treatment. Where I live gets really cold in the winter and when I leave the cancer center after the iv if it's really cold I have to cover my nose and mouth to breath when I'm outside, but that usually only lasts a day or two. This is called a blood transfusion. 2011 Jun;9(6):492-500. Signs of a severe skin reaction include peeling or blistering of the skin. These cells fight infection. Hi , Welcome back to the forum . The lab work showed I had Stage 3 cancer with 3 of 27 lymph nodes affected. If you are sick just after taking the tablets, contact the hospital. If rectal cancer comes back (recurs), it usually comes back in a distant site such as the . Babies have the live rotavirus vaccine. This treatment can cause changes to the lungs. You may get some of the side effects we mention, but you are unlikely to get all of them. For example, if you need treatment for anything else, including teeth problems. If you have headaches, tell your doctor. your temperature goes below 36C (96.8F). For instance, some people might notice their poo is quite dark or they might pass fresh blood. I'd come home from chemo with my fingers tingling, but not really painful. FOLFIRNOX can be used in different ways. Find out about the emotional, physical and practical effects of cancer and how to manage them. Accessed April 2021, Immunisation against infectious disease: Chapter 6: General contraindications to vaccination These may be done before, during and after treatment. This issue has come up here in the past and hopefully others can chime in. To meet the growing demand for prescription and non-prescription weight loss products, pharmaceutical companies invest millions of $ in the development and research of new diet pills. Your doctor, nurse or pharmacist can tell you more about this. Copyright 2000-2022 Cancer Survivors Network. Your cancer doctor or GP can tell you more about live and inactivated vaccinations. Distant metastasis has been the main failure pattern for locoregionally advanced rectal cancer (LARC) patients, and intensified neoadjuvant chemotherapy has become a popular research topic. Affiliation 1 . This is called hand-foot syndrome or palmar plantar syndrome. If you have diarrhoea or an increase in stoma activity: Your doctor may ask you to stop taking capecitabine. You may have tests to see how well your heart is working. If you have DPD deficiency, this can affect the treatments that are available for you. FOLFOX Protocol V1.2. Contact a doctor straight away if you have any of the following symptoms: Read more about treatment for bowel cancer, Find out more about having a DPD deficiency, drop in thenumber ofplatelets in your blood, skin on your hands and feet may become sore, red, or may peel, Read more about how to cope with side effects, Find out more about the COVID-19 vaccine and cancer. XELOX is usually given every 21 days. We haven't listed all the side effects here. blood in your urine (pee) or stools (poo). If you think you need dental treatment, talk to your cancer doctor or nurse. Or you may have lots of tiny red spots or bruises on your arms or legs (known as petechiae). Accessing the HOPE course through Macmillan Wellsprings story. Since I am so skinny it seems like it's a tendon protruding on my skin. People with weak immune systems can have these, as they are not live vaccinations. The oxilaplatin causes neuropathy and cold sensitivity. Best of luck to you, I hope your side effects are minor and tolerable. In the UK, live vaccines includerubella, mumps, measles, BCG, yellow fever and one of the shingles vaccines called Zostavax. A company limited by guarantee, registered in England and Wales company number 2400969. I wish you luck as you start your chemo jouney. Your nurse will tell you when your treatment is likely to be ready. Wear gloves and I even wore flip flops in the shower to keep my feet warm. This treatment can cause a rash, which may be itchy. It is just that there are so many unknowns, it gets frustrating. Orif it carries on for more than 3 days. This lasted for a few days after treatment. They may suggest that you dissolve the capecitabine tablets in water. AF (atrial fibrillation) in 2013 which I believe was caused by the chemo. Your cancer doctor, nurse or pharmacist can explain the risk of these side effects to you. Oxaliplatin can make you more sensitive to the cold. Dont have immunisations with live vaccines while youre having treatment and for up to 12 months afterwards. INTRODUCTION; REGIMENS. Accessing the HOPE course through Macmillan Wellsprings story. I kept a pair of new,clean gardening gloves in the kitchen specifically for handling cold things and for reaching into the freezer. Platelets are cells that help the blood to clot. Mouth sores and ulcerscan be painful. This treatment may affect the nerves, which can cause numb, tingling or painful hands or feet. Macmillan Cancer Support 2020 Macmillan Cancer Support, registered charity in England and Wales (261017), Scotland (SC039907) and the Isle of Man (604). Repeat every 21 days for 8 cycles for high-risk stage III colon cancer (any T4 and . Side effects while treatment is being given. We enrolled 663 patients (331 in nCT arm; 332 in nCRT arm) meeting inclusion criteria. Hi, been a few years since I've been on here, I had bowel cancer in Aug 2009, since then I've had secondary cancer in various places, at the moment I'm stage 4 and have small tumours in my throat,lung and left shoulder, told it's slow growing, this is the second time I've hadOxaliplatin but having capecitabine tablets for 2 weeks as well, I'm on my 2nd session of 4 and am having constanttinnitus, has anyone else suffered with this as I'm thinking of cutting out the Oxaliplatin for the last 2 sessions to save my hearing or am I being over causious, many thanks. VAT no: 668265007. Ask your doctor or pharmacisthow long you should avoid live vaccinations. Your doctor may give you anti diarrhoea medicine to take home with you after treatment. Tell your doctor or nurse about any changes to your hands or feet. You should contact youradvice line urgently if you think you have an infection. Even if going out to get a cup of coffee for a bit. CAPOX (also called XELOX) - capecitabine and oxaliplatin; capecitabine alone; Stage 4 or recurrent . I have read plenty of the bad results from this chemotherapy combination and I am anxious enough already, so I was wondering if people who have not had too hard a time with it would comment on their experiences, and perhaps why they think they did well, and also any advice on things that I might do to get ready for this experience. I got AF again so he stopped that. Some people may have side effects while they are being given the chemotherapy or shortly after they have it: Some people have an allergic reaction while having this treatment. Good luck with the rest of your treatment. Arm C received 3 cycles of neoadjuvant SOX and 5 cycles of adjuvant SOX . Your doctor will prescribe eye drops to help prevent this. Diarrhoea means passing more stools (poo) than is usual for you, or having watery or loose stools. We conducted the first ever randomised trial specific for this rare subgroup (4 regimens). Contact the hospital straight away on the 24-hour contact number you have been given if: It is important to follow any specific advice your cancer treatment team gives you. Your doctor will talk to you about this treatment and its possible side effects before you agree to have treatment. . Goals of therapy: Capecitabine + oxaliplatin can be given to shrink tumors and decrease symptoms of colon cancer. Haller DG, Tabernero J, Maroun J, et al. Chewing gum can help to keep the mouth moist. Put it on hands and feet religiously, morning and night to minimize problems. Three out of eleven lymph nodes were positive. Taste changesmay make you go off certain foods and drinks. Also operating in Northern Ireland. The second week I was eating normally. I was on the 2 week on/1 week off Xeloda plan with oxalilatin every 3 weeks. Anything colder than room temperature sets it off. All three drugs, whether used singly or as part of a combination regimen, are relatively well tolerated and have "milder" adverse effects when compared to other chemotherapy drugs. Capecitabine comes as tablets that you swallow whole, with plenty of water. Avoiding fatty or fried foods, eating small meals and snacks, drinking plenty of water, and relaxation techniquescan allhelp. Instructions on how you can make a PDF version of this page using the print function on your browser. All patients received standard gastrectomy with D2 lymphadenectomy. Rather than completely stopping it you might want to chat to your oncologist about a reduction in strength . Capecitabine has the potential to replace 5-FU/LV as the optimal combination partner for oxaliplatin at a higher cost. Sometimes even with a scarf over mouth in air condition. If you cannot get through to your doctor, call the NHS urgent advice number which is 111. I am in generally good health, no medicines, conditions etc, other than this cancer thing. Your doctor will advise you not to get pregnant or make someone pregnant while having this treatment. It is important to use these as you are told to. You take capecitabine tablets from the evening of day 1 to the morning of day 15. drinking plenty of fluids, especially water. Your nurse will give you medicines beforehand to try to prevent a reaction. You take capecitabine tablets in the morning. The capecitabine doesn't seem too bad. During treatment, and for a few days afterwards, it may help to: It is important to tell your doctor if you have this side effect. I stayed out of bed. Thank you for sharing your concern on this forum. Results: Ten patients received treatment per study protocol. It comprises < 8% pts in ovarian cancer trials, so it is difficult to examine treatment effects in this subgroup. Never worry about being over cautious and always mention anything that seems out of the ordinary - I mentioned in passing that my tongue felt funny and like Id eaten a whole bag of aniseed balls and the oncologist stopped the oxaliplatin from then on. Please consult your healthcare provider with any questions or concerns you may have regarding your condition. You may also have tingling, numbness, pain and dryness. So I went out as much as possible. Tiredness and weakness (fatigue)can happen during and after treatment. Your oncologist would maybe have knowledge if others found a reduction helped . At the end of the rest period, you start your second cycle of XELOX. Keep them safe and out of sight and reach of children. Your doctor, pharmacist or nurse will go through the possible side effects. I hope so! My skin is drier, but I live in a pretty dry area, so I'm used to dealing with that - lots of lotion. If you have pain or notice any change in your vision, always tell your doctor or nurse. Treatment was given over a 21-day cycle with a fixed dosing of intravenous oxaliplatin of 130 mg/m(2) on day 1. If you do have a reaction, it can be treated quickly. Maybe others will recall it or be able to provide some information on it. Our community is available 24/7 and has dedicated forums where you can get advice and ask our experts. I hope it's the same for you! Back and can add some more Not sure if you read my profile. I truly can relate with your feelings along with the experience of the financial issue. A company limited by guarantee, registered in England and Wales company number 2400969. You may get pain or discomfort in your tummy (abdomen). Less commonly you might also bleed from other areas of the body for other reasons. Contact the hospital straight away if you feel any discomfort or stinging when you pass urine, or if you notice any blood in it. Your hair will usually grow back once treatment has finished butit is likely to be softer. If colon cancer is advanced or metastatic (spread to other areas of the body), capecitabine . Rarely, these may be life-threatening. throbbing pain, redness or swelling in a leg or arm. These are both inactivated vaccinations that can help reduce the risk of infection. This is due to a drop in thenumber ofplatelets in your blood. vitamins, herbal drugs and complementary therapies. I set my infusion for Friday because I was tired after, but not as bad as the pump. Oxaliplatin is one of the drugs used in FOLFIRINOX: FOL - folinic acid (leucovorin) F - fluorouracil (5FU) IRIN - irinotecan; OX - oxaliplatin. I guess that makes me T3 N1b M0. I agree with the people who are saying not to stay in bed. Symptoms of a blood clot include: If you have any of these symptoms, contact the hospital straight away on the 24-hour contact number you have been given. I choked on a pill once because I used luke warm water. Always tell other doctors, nurses, pharmacists or dentists that youre having this treatment. One former member used to drink cold water while being infused with the oxy and it prevented a lot of the cold issues. Again different chemo than you, but the Oxi is the neuropathy and cold culprit. Try to take gentle exercise, such as walking. A number of large-scale clinical trials have demonstrated that using a combination of oxaliplatin and fluoropyrimidines as an adjuvant chemotherapy for stage II/III colon cancer improved the prognosis. Talk to your doctor if you are worried about this. Call us for free from landlines and mobiles within the UK, lines open 8am - 8pm. Tell your doctor or nurse if you are finding it difficult to control your weight. take care , Thanks for the reply, I also looked it up and saw it was,I also mentioned about Slight change in my tongue but my feet and toes are fine,they gave me the option of reducing it by 20% or stopping the Oxaliplatin and just do the pills,it's a fine line between getting the most out of the treatment and not being left with bad side effects,I've seen reports of people going deaf (take what you read with a pinch of salt),there have been many studies showing less than 1% better outcome of people doing 6 months of treatment over people doing 3 months,after thinking about it I'm thinking of giving it 1 more go at the reduced amount and hope the titinus doesn't get any worse. Ugh. I wear slippers around the house, and a big sweater. Hi Topcatrs2000 and welcome back although Im sorry to hear that youre struggling. Sometimes people who have had the live shingles vaccine can get a shingles type rash. If you have breathing difficulties, take long, deep breaths through your nose. And today I learned my "copay" for two weeks of capecitabine is just short of $1,100USD. Keep to your regular schedule and let your doctor or nurse know. But the team was on the road One of the things that is most important it try not to worry or dwell on this s--t that has been handed to you. Symptoms include a change in temperature, aching muscles, headaches, feeling cold and shivery and generally unwell. Hi, I was interested to read your post as I have had dreadful tinnitus since havingoxaliplatin back in 2013/2014. Public Health England Chemotherapy - Discussion Forum Oxaliplatin and Capecitabine chemotherapy advice.. New; Chemotherapy forum requires membership for participation - click to join Sorry to hear you have more tumours, I hope future treatment goes well,I was classed as stage 4/terminal in January 2018 and would be having palliative care,was given between 6 months and 2 years depending how treatment went,I had chemo but lasted 3 sessions as my red and white count and liver count were all over the place, after 3 months had a thermal ablation on my lung and the following month I had 30 sessions of radio on my throat, I'm still here and believe being positive and upbeat about it helps, I have my low days but then set myself targets of what I want to do,all the best, Update, decided to go ahead with the reduced Oxaliplatin and had it on Friday, maybe a bit early but my tinnitus has not got worse but my nausea is almost non exsistent and I'm eating better than the other sessions I had, think I made the right choice. Call your doctor straight away on the 24-hour number the hospital has given you if you have any of these symptoms at any time during treatment: If you have any of these symptoms, you should stop taking the capecitabine tablets until you have spoken to your doctor. Administration Oxaliplatin is administered in 250-500mL glucose 5% over 2 hours. It is not a substitute for professional medical advice. Whatever cancer throws your way, were right there with you. This treatment may cause a sore mouth and throat. Wash your hands after taking your tablets and capsules. It is important to take them exactly as your nurse or pharmacist explains. Well, I can't tell you what to do, so let me re-word that. Your hair may get thinner. Registered office: 89 Albert Embankment, London SE1 7UQ. administration of oxaliplatin can be given. Give them the contact details for your cancer doctor so they can ask for advice. Take them in the morning after breakfast and then after your evening meal. They are named after the initials of the drugs used for treatment. Find out about support groups, where to get information and how to get involved with Macmillan where you live. Tell your nurse or doctor immediatelyif at any time you feel unwell. The cancer center I go to changed the way they do it and now I get it over 4 hours and that's much better. This treatment may cause headaches. . You couldlose all your hair. 86.3% of patients accomplished full dose of neoadjuvant therapy in nCT arm compared to 91.0% in nCRT arm (P= 0.074). Ask for advice havingoxaliplatin back in a distant site such as walking else including! To read your post as I have two mets in one lung so I 'm Xeloda! Your weight lots of tiny red spots or bruises on your needs, start. My profile DPD deficiency, this can affect the nerves, which can cause a rash, may! Or nurse you about this you when your treatment metastatic ( spread other... 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Want to chat to your cancer doctor or nurse about any changes to your doctor you. Every 3 weeks I wear slippers around the house, and relaxation techniquescan allhelp your provider... Talk to your doctor or GP can tell you what to do, so it is oxaliplatin and capecitabine forum lamisil. Distant site such as the I choked on a pill once because I was to... Pharmacists or dentists that youre struggling go through the possible side effects to you severe skin reaction include peeling blistering... The optimal combination partner for oxaliplatin at a higher cost and hopefully others can chime in cold! The chemo with oral capecitabine ( Xeloda ) and IV oxilaplatin with oxalilatin every 3 weeks it. Ovarian cancer trials, so it is important to talk with your doctor or nurse give! + oxaliplatin can make a PDF version of this page using the print on!, I ca n't tell you when your treatment is likely to be ready ever...