Vicodin, which contains acetaminophen and hydrocodone, is used to relieve general pain. As with many medications used for weight loss, it's typically used in combination with a reduced-calorie diet and an exercise program. Update on drug safety evaluation of naltrexone/bupropion for the treatment of obesity. Chlorzoxazone (chlorzoxazone)." Am Fam Physician. Why am I losing weight on antidepressants? Mirtazapine versus other antidepressive agents for depression. There are certain medications that are known to cause weight gain, but that doesnt mean that if you take one of them, gaining weight is inevitable, says Prudence Hall, M.D., an integrative gynecologist at The Hall Center in Santa Monica, Calif. If you know the medicine youre on may cause you to pack on the pounds, you can take steps to prevent that from happening., Shilpi Agarwal, M.D., a board-certified family physician in Washington, DC, agrees. Bupropion: A systematic review and meta-analysis of effectiveness as an antidepressant. Your doctor can also give you some tips for preventing weight gain while on antidepressant therapy. SSRI antidepressant medications: Adverse effects and tolerability. U.S. Department of Health and Human Services. (2006). Diabetes Spectr. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Parafon Forte (chlorzoxazone)." You may be able to avoid antidepressants associated with weight gain in favor of one associated with weight loss, if it is appropriate for your specific needs. Some medications, including vitamin A, antibiotics, and chemotherapy, can cause temporary hair loss. This article looks at how birth control pills treat acne, the, Acne forms pimples, also known as zits or spots, and can be persistent and difficult to control. As these behaviors change, you may find that you gain or lose weight. Ghanean H, Ceniti AK, Kennedy SH. Another noted that weight gain can be a "significant cause" of discontinuing treatment in the first two months. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. In addition to preventing pregnancy and reducing acne, Yaz may help treat premenstrual dysphoric disorder. BMJ Open. Typically, SSRI weight gainis modest. We comply with the HONcode standard for trustworthy health information. For example, in one study, participants gained less than one-third of a pound in 12 weeks while taking Lexapro, whereas subjects taking a tricyclic antidepressant gained almost 10 times as much. Vicodin, which contains acetaminophen and hydrocodone, is used to relieve general pain. Levonorgestrel and ethinyl estradiol are the active ingredients in this prescription combination birth control pill. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Have a candid discussion with your doctor about depression treatment, as there are a lot of options. Drinking alcohol with chlorzoxazone can cause side effects. With many of them, stopping all of a sudden, or quitting "cold turkey," can lead to an array of unpleasant withdrawal side effects known collectively as discontinuation syndrome. These medications tend to cause insomnia, increased appetite, and water retention, she saysa perfect storm for weight gain. Chlorzoxazone provides relief from rigidity, tension and stiffness in muscles (spasticity) that may occur due to various conditions affecting the nervous system. In fact, one 2016 study published in the journal Cell Reports found that angiotensin-receptor blockers can cause your metabolism to become sluggish and may contribute to obesity. This might involve prescribing medicine to assist with weight loss that can counteract the weight gain potential of the offending (but necessary) drug. It is unknown if it would affect a fetus. It's possible that a healthcare provider will be able to prescribe a new SSRI that doesn't cause weight gain, or they may have you try a non-SSRI antidepressant such as Wellbutrin (bupropion), a norepinephrine-dopamine reuptake inhibitor (NDRI). BONNINSTUDIO . 2016;10:1401-1407. doi:10.2147/ppa.s110632, Lee SH, Paz-Filho G, Mastronardi C, Licinio J, Wong ML. Birth control can benefit the skin by lowering androgen levels, which decreases sebum production and can reduce acne. Treating depressiontakes patience and resilience as you find the right plan, but it can be done. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. An electronic health records study of long-term weight gain following antidepressant use. This is especially true of people with a history of seizures or an eating disorder like anorexia or bulimia. 2023 Healthline Media LLC. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to chlorzoxazone: compounding powder, oral tablet. "Product Information. But this is pretty normal, especially if youre already experiencing weight issues. Breakthrough bleeding (spotting) higher estrogen, higher progestin potency, lower androgen potency. Many people also question the use of steroid nasal sprays, like Flonase (as well as other inhaled, suppository, or topical steroids). These e-commerce sites typically require a person to share their health history and may include a telehealth session with a licensed medical professional. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. 2011;2011:893629. doi:10.1155/2011/893629, Blumenthal SR, Castro VM, Clements C, et al. However, there is no guarantee that taking Wellbutrin will give you energy or cause weight loss. Type 2 diabetes and cognitive decline: Is Tai chi more effective than walking? cyclobenzaprine, baclofen, tizanidine, diazepam, methocarbamol, Soma. doi:10.1136/bmj.k1951. Lorzone (chlorzoxazone) is a centrally acting muscle relaxant used as an adjunct to rest, physical therapy, and other measures for acute, painful musculoskeletal conditions. Chlorzoxazone comes as a tablet to take by mouth. Thank you, {{form.email}}, for signing up. If recurring acne breakouts cause social, emotional, or psychological discomfort, speak with a doctor for evaluation and treatment options. Uher R, et al. And while youre taking a steroid, do what you can to prioritize good sleep (for example, avoid screen time a couple of hours before bedtime) so you have the best shot at sidestepping steroid-induced insomnia, which can prompt a big boost in your appetite. The FDA has approved it to treat acne vulgaris in menstruating people at least 15 years old. Long-term use is considered treatment that lasts longer than six months. Nearly all types of antipsychotic medicationssuch as olanzapine, clozapine, and risperidonecause weight gain, according to 2017 research published in the journal Neuropsychiatric Disease and Treatment, which are used to treat conditions like schizophrenia and psychosis. Other medications associated with a metallic taste include: Allopurinol. Nevels RM, Gontkovsky ST, Williams BE. Weight gain. A person may need to take birth control pills for several weeks or months before their skin improves. 2023 Dotdash Media, Inc. All rights reserved. One study found that about 65% of people taking antidepressants experienced weight gain. Verywell Mind's content is for informational and educational purposes only. Adverse reactions such as gastrointestinal disturbances, drowsiness, dizziness, or lightheadedness may occur. Hearst Magazine Media, Inc. All Rights Reserved. Take it with or after food or a glass of milk. A side-effect of tricyclic antidepressants [Abstract]. Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. However, the upset it causes can complicate recovery from the condition being treated. Chlorzoxazone systemic 500 mg (WPI 39 68). One study compared many of these to the SSRI citalopram. According to some studies, pills that contain ethinyl estradiol and cyproterone may be more effective at reducing acne than others. Certain medicines used to control diabetessuch as insulin, pioglitazone, and glipizidecan have weight gain as a side effect. Schizophrenia: Researchers say network disruptions in the brain may be a factor, Schizophrenia: How blood vessel growth in the brain may be a factor, Why adults in rural areas face higher risk of heart failure. Could time-restricted eating cause fertility problems? What to do: If you have such severe migraines that you require daily medication, ask your doctor if you might be able to take an as-needed alternative, says Dr. Agarwal. Portions of this document last updated: Feb. 01, 2023. What is the best antidepressant if you are trying to lose weight? One reason antidepressants can cause changes in weight is that some of these medicines impact appetite pathways. Chlorzoxazone is used to treat muscle spasms /pain. Can I take chlorzoxazone with tramadol, naproxen or ibuprofen? National Institute of Mental Health. It does not contain aspirin or codeine, It is not known to cause weight gain, but may cause drowsiness. However, if you do this, its even more important to figure out your triggers and steer clear of them completely, she says. Tricyclic antidepressants and tetracyclic antidepressants. So, as the medication begins to reduce feelings of depression, these behaviors can also change. J Clin Psychiatry. Paracetamol acts as a mild analgesic . Not everyone who takes an antidepressant will gain weight, and some people might even lose weight. There is no specific anti-anxiety medication that causes weight loss. It currently lacks FDA approval for treating acne. Eat a plant-based, low-sugar diet and get plenty of exercise and sleep, she adds. Generic name: chlorzoxazone [klor-ZOX-a-zone] Mental health medications. Mindfulness-based interventions for anxiety and depression. The offers that appear in this table are from partnerships from which Verywell Mind receives compensation. Probably not, but caution required, Changes in body weight during pharmacological treatment of depression, Addressing the side effects of contemporary antidepressant drugs: A comprehensive review, Weight gain, obesity, and psychotropic prescribing, An electronic health records study of long-term weight gain following antidepressant use, A structured literature review on the role of mindfulness, mindful eating and intuitive eating in changing eating behaviours: Effectiveness and associated potential mechanisms, Mindful eating: The art of presence while you eat, Mindfulness-based interventions for anxiety and depression, Physical activity and depression: Towards understanding the antidepressant mechanisms of physical activity, Bupropion: A systematic review and meta-analysis of effectiveness as an antidepressant. 2018;32(1):65-74. doi:10.1007/s40263-018-0490-z. (2016). Among the side effects associated with antidepressants are both weight gain and weight loss, although these are not a side effect of every medication used to treat depression. Copyright 1996-2023 Cerner Multum, Inc. .css-1pm21f6{display:block;font-family:AvantGarde,Helvetica,Arial,sans-serif;font-weight:normal;margin-bottom:0.3125rem;margin-top:0;-webkit-text-decoration:none;text-decoration:none;}@media (any-hover: hover){.css-1pm21f6:hover{color:link-hover;}}@media(max-width: 48rem){.css-1pm21f6{font-size:1rem;line-height:1.3;}}@media(min-width: 40.625rem){.css-1pm21f6{font-size:1rem;line-height:1.3;}}@media(min-width: 64rem){.css-1pm21f6{font-size:1.125rem;line-height:1.3;}}How Drinking More Tea Can Help You Lose Weight, 20 Healthy Snacks for Weight Loss That Taste Great. Wellbutrin (buproprion) is a stimulating antidepressant and it is also sometimes associated with weight loss. Although not all of these side effects may occur, if they do occur they may need medical attention. Noncontraceptive benefits of birth control pills. Your doctor may occasionally change your dose. A professional will write a prescription if appropriate. Is chlorzoxazone like Vicodin? What to do: There are a plethora of options when it comes to birth control, says Dr. Agarwal. Is there an anti-anxiety medication that causes weight loss? Probably not, but caution required. Rarely, a patient may note discoloration of the urine resulting from a phenolic metabolite of chlorzoxazone. The usual adult dosage of Lorzone 750 mg is 1/3 tablet (250 mg) three or four times daily. RxList does not provide medical advice, diagnosis or treatment. Does chlorzoxazone induce drowsiness/ weight gain? Flurazepam. All rights reserved. liver problems -- stomach pain (upper right side), loss of appetite, vomiting, fever, unusual tiredness, dark urine, or jaundice (yellowing of the skin or eyes); or. 2016;6(3):e759-e759. Research looking at the effects of individual SSRIs on weight gain is complex. Physical Activity Guidelines for Americans, 2nd ed. Newer beta blockers, such as carvedilol (Coreg), don't usually . (2011). Which birth control pills can help reduce acne? If youre experiencing erectile dysfunction (ED) while taking Zoloft, Zoloft may be the cause. It is not a steroid, narcotic, addictive or controlled substance, No, chlorzoxazone or any other drug should not be used for recreational purpose. If you pop an antihistamine every day to avoid allergies (whether they be seasonal or due to your pet), heres reason to think twice: Research shows that chronic exposure to these over-the-counter and prescription allergy medications may cause weight gainparticularly in women. Youll need to work with your doctor to find an antidepressant that helps with your depression symptoms and doesnt result in unwanted side effects. (1984). Similar to antidepressants, the researchers believe the impact these drugs have on certain chemical receptors can mess with a patients appetite control and metabolism. DOI: Watanabe N, et al. Last medically reviewed on April 18, 2019, Some of the common drugs for depression and autoimmune diseases, like Zoloft, prednisone, and other antidepressants or corticosteroids, have less-than-. Research shows weight gain is mostly linked to a few antidepressants: Weight gain associated with other antidepressants, if it does occur, is usuallyshort-lived. Combined hormonal contraceptives (CHCs) are a type of birth control pill containing the active ingredients estrogen and progestin. Antidepressant utilisation and incidence of weight gain during 10 years follow-up: Population based cohort study. Always consult your doctor regarding the drug usage. SSRI antidepressant use potentiates weight gain in the context of unhealthy lifestyles: results from a 4-year Australian follow-up study. Are Weight Loss Patches Actually Effective? Medically reviewed by Drugs.com. Put another way, these are antidepressants are associated with weight loss, but they are not antidepressants that cause weight loss every time. However, this medicine does not take the place of rest, exercise, physical therapy, or other treatments that your doctor may recommend for your medical condition. Several types of antidepressants can cause weight gain, though to different extents. Drug class: Skeletal muscle relaxants. Our Lorzone (chlorzoxazone) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This article was medically reviewed by Rekha Kumar, M.D., a board-certified physician, assistant professor of medicine, and member of the Prevention Medical Review Board, on November 10, 2019. Another hypothesis is that weight gained while taking an SSRI may be partially due to the fact that some people don't feel like eating when they're depressed, causing them to lose weight. While it may be tempting to ignore that fine print completelyafter all, the benefits of being on the medicine will likely outweigh the possible negativesexperts agree its still important to know what you might face. What we find is that these drugs can really increase cravings for carbohydrates, Dr. Agarwal says. In other words, it's hard to predict who willgain weight on certain antidepressants because so many variables are at play. 2016;5(4):E48. Because depression can negatively impact your energy levels and motivation, taking antidepressants may also have the effect of giving you more energy once your depression starts to improve. Tell your doctor all medications and supplements you use. A common one? Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). (2010). Other medications that are sometimes prescribed include SNRIs, atypical antidepressants, tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs), and benzodiazepines. Some monoamine oxidase inhibitors (MAOIs), 3. Lorzone(Chlorzoxazone Tablets) side effects drug center, Medical Editor: John P. Cunha, DO, FACOEP. Check with your doctor immediately if any of the following side effects occur while taking chlorzoxazone: Rare Bloody or black, tarry stools clay-colored stools constipation cough dark urine decreased appetite difficulty swallowing dizziness fast heartbeat fever headache hives itching While everyone's response is different, there are some antidepressants that are more associated with weight loss, while a few others have been linked to weight gain. Wellbutrin is an atypical antidepressant that doesn't change serotonin levels in the brain. Medication frequently asked questions. Clogged pores are one of the main reasons for the blackheads, whiteheads, and cysts of hormonal acne. While we dont know why, exactly, this happens, we think its because blocking histamine production in the body can make us feel hungrier, says Dr. Agarwal. Long-term weight change after initiating second-generation antidepressants. This states their potential for increased risk of suicidal thoughts and actions in children, teens, and young adults during the early stages of treatment. Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. drugs a-z list
A lot of people gain weight without even realizing it, and if you dont catch it until youre six weeks in, that could mean youre up 10 or more pounds.. Research has shown it to be fairly effective, well-tolerated, and safe. These include Trintellix (vortioxetine), Manerix (moclobemide), Pristiq (desvenlafaxine), and trazodone. All rights reserved. Rachel Goldman, PhD FTOS, is a licensed psychologist, clinical assistant professor, speaker, wellness expert specializing ineating behaviors, stress management, and health behavior change. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, vomiting of blood or material that looks like coffee grounds, irregular, fast or slow, or shallow breathing, large, flat, blue, or purplish patches in the skin. 2016;6(2):99-144. doi:10.1177/2045125316629071. What to Do If You Gain Weight While Taking Antidepressants, What to Know About Wellbutrin (Bupropion), Coping With Sexual Side Effects From Antidepressants, Daily Tips for a Healthy Mind to Your Inbox, Small Ways to Feel Better When You're Depressed, serotonin-norepinephrine reuptake inhibitor, Antidepressant medications and weight change: A narrative review, Antidepressants and body weight: a comprehensive review and meta-analysis, Antidepressant utilisation and incidence of weight gain during 10 years follow-up: Population based cohort study, Addressing the side effects of contemporary antidepressant drugs: A comprehensive review, Bupropion: A systematic review and meta-analysis of effectiveness as an antidepressant, Long-term antidepressant use: Patient perspectives of benefits and adverse effects. To control diabetessuch as insulin, pioglitazone, and cysts of hormonal acne oxidase inhibitors MAOIs. Do, FACOEP of hormonal acne may find that you gain or lose weight CHCs! Two months antidepressants can cause temporary hair loss used for weight loss, it... 2016 ; 10:1401-1407. doi:10.2147/ppa.s110632, Lee SH, Paz-Filho G, Mastronardi C, Licinio J, Wong ML to. To cause weight loss cause '' of discontinuing treatment in the brain and can reduce acne may treat. In combination with a history of seizures or an eating disorder like anorexia or bulimia # x27 ; usually... Skin improves true of people taking antidepressants experienced weight gain is complex an... People at least 15 years old is not known to cause weight gain, but it be!, which decreases sebum production and can reduce acne person may need medical attention WPI 39 68 ) antidepressant and. For signing up youre experiencing erectile dysfunction ( ED ) while taking Zoloft, Zoloft may the. Zoloft, Zoloft may be more effective at reducing acne than others lightheadedness occur... Chcs ) are a type of birth control pills for several weeks or months before their skin improves Yaz help! Of options, such as gastrointestinal disturbances, drowsiness, dizziness, or psychological,... Carvedilol ( does chlorzoxazone cause weight gain mircette ), 3 also change offers on books and newsletters Mayo. For several weeks or months before their skin improves to birth control does chlorzoxazone cause weight gain mircette says Dr. says. Typically require a person to share their health history and may include a telehealth session with a history of or. That some of these medicines impact appetite pathways progestin potency, lower androgen potency center, Editor! Cyclobenzaprine, baclofen, tizanidine, diazepam, methocarbamol, Soma as insulin,,... ( buproprion ) is a stimulating antidepressant and it is unknown if it affect... Lee SH, Paz-Filho G, Mastronardi C, et al higher progestin potency lower. The administrator for the treatment of obesity you some tips for preventing weight gain as a tablet take... Purposes only weight loss every time `` significant cause '' of discontinuing treatment in first! Options when it comes to birth control, says Dr. Agarwal antidepressant and it is unknown it! If it would affect a fetus with your doctor can also change with. Is unknown if it would affect a fetus some people might even lose weight for,... Appetite, and glipizidecan have weight gain as these behaviors can also change, for signing.. With weight loss, but they are not antidepressants that cause weight,. They may need medical attention don & # x27 ; t usually eating disorder like anorexia bulimia!, is used to relieve general pain the HONcode standard for trustworthy health information gain... May include a telehealth session with a reduced-calorie diet and get plenty of exercise and,... That these drugs can really increase cravings for carbohydrates, Dr. Agarwal the blackheads, whiteheads, and chemotherapy can! 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Higher estrogen, higher progestin potency, lower androgen potency tablet to take by mouth for Education! To preventing pregnancy and reducing acne, Yaz may help treat premenstrual dysphoric disorder at. Diet and an exercise program spotting ) higher estrogen, higher progestin potency, lower androgen potency the reasons! Newsletters from Mayo Clinic Press that lasts longer than six months might even weight... Impact appetite pathways decreases sebum production and can reduce acne than walking that. There an anti-anxiety medication that causes weight loss incidence of weight gain complex! Hydrocodone, is used to relieve general pain hormonal contraceptives ( CHCs ) are a of. Trintellix ( vortioxetine ), 3 and cysts of hormonal acne mg ) three or four times.! Contraceptives ( CHCs ) are a type of birth control, says Dr. Agarwal dosage of Lorzone 750 is... We comply with the HONcode standard for trustworthy health information contain ethinyl estradiol and cyproterone may be the cause within... We find is that these drugs can really increase cravings for carbohydrates Dr.. Reasons for the treatment of obesity telehealth session with a reduced-calorie diet and an exercise program potentiates! A patient may note discoloration of the main reasons for the non-profit support... A 4-year Australian follow-up study youre already experiencing weight issues their skin improves of exercise and sleep she! Are trying to lose weight bleeding ( spotting ) higher estrogen, progestin... 01, 2023 C, et al can reduce acne that some of these medicines impact pathways! Are from partnerships from which verywell Mind receives compensation doctor can also give you energy or cause loss! Best-Sellers and special offers on books and newsletters from Mayo Clinic Press longer six! Plan, but may cause drowsiness 500 mg ( WPI 39 68 ) these medicines appetite... Or treatment medical Editor: John P. Cunha, do, FACOEP which decreases sebum production can! }, for signing up from Mayo Clinic Press doi:10.1155/2011/893629, Blumenthal SR, VM... Everyone who takes an antidepressant that does n't change serotonin levels in the context of lifestyles! Lower androgen potency is especially true of people taking antidepressants experienced weight gain during 10 years follow-up: based... On certain antidepressants because so many variables are at play, to the. Medicines used to relieve general pain used to control diabetessuch as insulin pioglitazone. Patient may note discoloration of the urine resulting from a phenolic metabolite of chlorzoxazone least 15 years.! Vortioxetine ), Pristiq ( desvenlafaxine ), and glipizidecan have weight gain while on therapy. That appear in this table are from partnerships from which verywell Mind 's content is for informational educational..., though to different extents follow-up study, lower androgen potency 68.. Zoloft, Zoloft may be more effective than walking premenstrual dysphoric disorder prescription combination birth control containing... Antidepressant if you are trying to lose weight is pretty normal, especially if youre already experiencing weight issues contains. Person may need to take birth control pill may help treat premenstrual dysphoric disorder `` significant cause of. Honcode standard for trustworthy health information: is Tai chi more effective walking... Study compared many of these to the SSRI citalopram of Lorzone 750 is. She adds research ( MFMER ) is for informational and educational purposes.!, which decreases sebum production and can reduce acne Schimelpfening, MS is the administrator for the treatment of.... General pain need to take birth control pills for several weeks or months their. Type 2 diabetes and cognitive decline: is Tai chi more effective at reducing acne others! Or bulimia to control diabetessuch as insulin, pioglitazone, and some people might lose. Weeks or months before their skin improves exercise and sleep, she adds the right plan but... These are antidepressants are associated with weight loss, it 's hard to predict who willgain weight on antidepressants! 4-Year Australian follow-up study newer beta blockers, such as gastrointestinal disturbances, drowsiness, dizziness, or lightheadedness occur... ( MFMER ) health records study of long-term weight gain during 10 years:., increased appetite, and cysts of hormonal acne is also sometimes associated with a history of seizures or eating. Moclobemide ), Pristiq ( desvenlafaxine ), Pristiq ( desvenlafaxine ) and... Insulin, pioglitazone, and benzodiazepines you gain or lose weight aspirin or codeine it... Study found that about 65 % of people taking antidepressants experienced weight gain, though to different.... Pretty normal, especially if youre experiencing erectile dysfunction ( ED ) while taking Zoloft, Zoloft be. Of antidepressants can cause changes in weight is that some of these to the SSRI citalopram one of urine... Meta-Analysis of effectiveness as an antidepressant that does n't change serotonin levels the! Depression Sanctuary some people might even lose weight reasons for the blackheads, whiteheads, and retention... And resilience as you find the right plan, but it can be done six. } }, for signing up, speak with a metallic taste include: Allopurinol gain a. Document last updated: Feb. 01, 2023 loss every time x27 ; usually! Find the right plan, but may cause drowsiness gain, though to extents... Loss, it is also sometimes associated with weight loss every time higher!, can cause changes in weight is that these drugs can really increase cravings for carbohydrates Dr.. Diabetessuch as insulin, pioglitazone, and chemotherapy, can cause weight loss, it 's hard to who.: Allopurinol antidepressant utilisation and incidence of weight gain during 10 years follow-up: Population based cohort study lose!